Current Prevalence Of Obesity Research Articles

Sex differences in energy metabolism: natural selection, mechanisms and consequences.

Metabolic homeostasis operates differently in men and women. This sex asymmetry is the result of evolutionary adaptations that enable women to resist loss of energy stores and protein mass while remaining fertile in times of energy deficit. During starvation or prolonged exercise, women rely on oxidation of lipids, which are a more efficient energy source than carbohydrates, to preserve glucose for neuronal and placental function and spare proteins necessary for organ function. Carbohydrate reliance in men could be an evolutionary adaptation related to defence and hunting, as glucose, unlike lipids, can be used as a fuel for anaerobic high-exertion muscle activity. The larger subcutaneous adipose tissue depots in healthy women than in healthy men provide a mechanism for lipid storage. As female mitochondria have higher functional capacity and greater resistance to oxidative damage than male mitochondria, uniparental inheritance of female mitochondria may reduce the transmission of metabolic disorders. However, in women, starvation resistance and propensity to obesity have evolved in tandem, and the current prevalence of obesity is greater in women than in men. The combination of genetic sex, programming by developmental testosterone in males, and pubertal sex hormones defines sex-specific biological systems in adults that produce phenotypic sex differences in energy homeostasis, metabolic disease and drug responses.

Obesity: Overview of a Universal Health Conundrum

Obesity is a worldwide health issue which is displaying increasing prevalence trend. World Health Organisation (WHO) has already given it a epidemic status. Many physiological parameters such as Body Mass Index (BMI), Waist Circumference (WC), Waist to Hip Ratio (WHR) are used for measurement of obesity. This review was written with the aim to give an inclusive picture of current prevalence of obesity along with discussing the physiology and function of different adipocytes and the numerous chemical messengers released by them. The manifold impact of obesity on various body systems can be elucidated by exploring the adipocytes, adipokines its functions and signalling mechanism. The adipokines enlist as key players in numerous systemic diseases. Obesity has a significant pathophysiological role in morbidity and mortality causing conditions globally. Obesity can potentially be the leading reason of economic burden on global health care, adversely impacting the comprehensive quality of life. This review is an effort to provide a better understanding of the current obesity status and emphasise further researches on its diverse aspects.

Timing of Meals and Exercise Affects Hormonal Control of Glucoregulation, Insulin Resistance, Substrate Metabolism, and Gastrointestinal Hormones, but Has Little Effect on Appetite in Postmenopausal Women.

The current prevalence of obesity in the US is strongly associated with excessive food intake and insufficient physical activity. This study examined whether changing the timing of exercise before or after two daily meals could alter human appetite for food. Fifty-four healthy postmenopausal women were matched by body weight and assigned to two groups: (1) two bouts of 2-h moderate-intensity exercise ending one hour before each weight-maintenance meal (XM, n = 23), (2) two-hour moderate-intensity exercise starting 1 h after each weight-maintenance meal (MX, n = 23), and one sedentary control (SED) arm (n = 8). Measurements included appetite ratings, circulating glucose, free fatty acids (FFAs), a ketone body D-ß-hydroxybutyrate (BHB), glucoregulatory hormones insulin and glucagon, and gastrointestinal hormones associated with food digestion and absorption and implicated in appetite sensations. XM group increased concentrations of FFAs and BHB during exercise and increased insulin and homeostatic assessment of insulin resistance (HOMA-IR) during postprandial periods. MX group reduced postprandial insulin and HOMA-IR by about 50% without a major change in plasma glucose. There was brief suppression of hunger and an increase in satiation in both exercise groups near the end of the first postprandial period. The time course of hunger was unrelated to the perturbations in fuel metabolism, depletion of liver glycogen, and not correlated with concentration changes in hunger-stimulating hormone ghrelin during XM exercise before meals. Similarly, there was no correlation between the time course of fullness during exercise after meals with the postprandial secretion of gastrointestinal hormones including cholecystokinin (CCK) that has been linked to satiation. Hunger and satiation appear to depend on oral intake and gastrointestinal processing of nutrients and are not affected by metabolic and hormonal consequences of the timing of exercise with respect to meals. Moderate-intensity exercise performed shortly after meals induces a rapid and highly effective lowering of insulin resistance.

Obesity in Saudi Arabia in 2020: Prevalence, Distribution, and Its Current Association with Various Health Conditions.

The global prevalence of obesity is increasing. Obesity is associated with many chronic diseases and health conditions. This study aims to estimate the current prevalence of obesity in Saudi Arabia and described the current national-level status of the association between obesity and various health conditions. This study is a nationwide cross-sectional survey conducted over phone-interviews in June 2020. In this study, a proportional quota-sampling technique was used to obtain equal distributions of participants, stratified by age and gender, across the 13 regions of Saudi Arabia. Weight and height were self-reported, and the obesity was determined as BMI ≥ 30. Logistic regression adjusted for age and gender was used for exploring current associations between obesity and health conditions. Of the 6239 participants contacted, 4709 participants responded and completed the interview with a response rate of 75.48%. Of them, 50.1% were female, the mean age was 36.4 ± 13.5 (Range: 18–90), and the median age was 36. The national weighted prevalence of obesity (BMI ≥ 30) was 24.7%, and the prevalence in the sample (unweighted) was 21.7%. Obesity was significantly associated with type 2 diabetes [Odd ratio, (OR) = 1.52], hypercholesterolemia (OR = 1.69), hypertension (OR = 1.61), lung diseases (OR = 1.69), rheumatoid arthritis (OR = 1.57), sleep apnea (OR = 1.82), colon diseases (OR = 1.31), and thyroid disorders (OR = 1.8). This study provides an update on the recent prevalence of obesity in Saudi Arabia. It also shows the variation in prevalence rates between different regions, which might be explored further. Although obesity shows a decreasing trend, almost one-quarter of this study sample were obese. Obesity is currently associated with many health conditions that can affect the individuals’ quality of life, impose stress on the healthcare system and impose an economic burden on the country. This evidence highlights the need for action to focus more on obesity in Saudi Arabia.

The State of Obesity in Kansas: A Community Based Approach to Chronic Care Management.

Based on the current prevalence of obesity and projected growth rates, approximately 50% of all adults ages 18 and older in the United States will be obese within the next 10 years.1 The state of Kansas is projected to have greater obesity rates than the national average during this timeframe at 55.6% of the population. Current estimates rank Kansas 12th in the nation for obesity prevalence, with 34.4% of adults ages 18 and older who are obese, and 39th in the nation for childhood obesity with 12.5% of the population ages 0 – 17 with obesity.2–4 The increasing prevalence of obesity is associated with a variety of factors including: socioeconomic status, ethnic and racial disparities, genetics, geographic location, age, disability status, pregnancy, associated comorbid medical conditions, access to food, cultural beliefs, and health behaviors.5–20 Socioeconomic factors including income level, education, ethnicity, race, unemployment, and geographic location have a significant influence on the development of obesity (Figure 1).1,5–10 Obesity prevalence is correlated negatively with income level, with increased rates of obesity noted in low income populations. Individuals with limited financial means often live in food deserts and gravitate toward convenient food sources that are highly processed, low in nutrient density, and high in caloric content with a long shelf life. Within the city of Wichita, there are 44 square miles of food deserts where individuals live more than 1 mile from a grocery store.12 With limited access to food, individuals within these neighborhoods increasingly utilize convenience stores that are located within walking distance. A study conducted by the Health and Wellness Coalition of Wichita in 2013 showed that convenience stores make up 40% of the retailers within Wichita, but only 44% offer fresh fruits and 9% offer fresh vegetables.12 The cost associated with fresh produce at these locations can be up to four times the cost of fresh produce purchased from grocery stores. Open in a separate window Figure 1 The impact of socioeconomic factors on the development of obesity rates within the state of Kansas. Rates reflect self-reported survey data and likely underestimate the true prevalence and the effect of demographics on the development of this disease. [Figure created with BioRender.com.]

Transection of Gustatory Nerves Differentially Affects Dietary Fat Intake in Obesity-Prone and Obesity-Resistant Rats.

The current prevalence of obesity has been linked to the consumption of highly palatable foods and may be mediated by a dysregulated or hyposensitive orosensory perception of dietary fat, thereby contributing to the susceptibility to develop obesity. The goal of the current study was to investigate the role of lingual taste input in obesity-prone (OP, Osborne-Mendel) and obesity-resistant (OR, S5B/Pl) rats on the consumption of a high-fat diet (HFD). Density of fungiform papillae was assessed as a marker of general orosensory input. To determine if orosensory afferent input mediates dietary fat intake, surgical transection of the chorda tympani and glossopharyngeal nerves (GLX/CTX) was performed in OP and OR rats and HFD caloric intake and body weight were measured. Fungiform papillae density was lower in OP rats, compared with OR rats. GLX/CTX decreased orosensory input in both OP and OR rats, as measured by an increase in the intake of a bitter, quinine solution. Consumption of low-fat diet was not altered by GLX/CTX in OP and OR rats; however, GLX/CTX decreased HFD intake in OR, without altering HFD intake in OP rats. Overall, these data suggest that inhibition of orosensory input in OP rats do not decrease fat intake, thereby supporting that idea that hyposensitive and/or dysregulated orosensory perception of highly palatable foods contribute to the susceptibility to develop obesity.

Current and Past Obesity in Japanese Patients with Critical Limb Ischemia Undergoing Revascularization.

Aim: Recent studies suggested that past history of obesity or maximum body mass index (BMI) in the past was a strong prognostic predictor in a general population. The current study aimed to survey the distribution of current and maximum BMIs and to investigate their prognostic impact in patients with critical limb ischemia (CLI), whose prognosis was poor even after revascularization.Methods: We analyzed a database of a prospective, multicenter registry in Japan, including 499 CLI patients undergoing revascularization. Their current and maximum BMIs were surveyed at registration. The distribution and the impact on the prognosis were explored.Results: The estimated means (95% confidence intervals) of current and maximum BMIs were respectively 22.0 (21.7 to 22.3) and 25.3 (24.8 to 25.8) kg/m2; the difference was 3.3 (2.9 to 3.7) kg/m2. The prevalence of current obesity (BMI ≥ 25 kg/m2) was 18% (15% to 22%), whereas 48% (43% to 53%) had ever been obese (maximum BMI ≥ 25 kg/m2). Past obesity was not rare even in currently lean subjects (BMI < 18.5 kg/m2), with the prevalence of 18% (7% to 29%). Current BMI, but not maximum BMI, was associated with the mortality risk; the adjusted hazard ratios per 5 kg/m2 increase were 0.61 [0.46, 0.81] (P = 0.001) and 1.07 [0.87, 1.31] (P = 0.55), respectively.Conclusion: The prevalence of current obesity was as low as 18% (15% to 22%) in Japanese CLI patients undergoing revascularization, whereas about a half were formerly obese. Maximum BMI was not independently associated with the mortality risk in the population.

Associations Between Obesity and Pediatric Foot Dimensions.

The influence of childhood obesity on shape and structure of the pediatric foot remains poorly understood. The purpose of this work was to determine associations between obesity and pediatric foot dimensions. A retrospective analysis of pediatric foot dimensions (foot length [FL] and foot width [FW]) in 3,713 children aged 3 to 18 years was undertaken. Logistic regression was used to determine relationships between FL, FW, and weight category. Compared with obese peers, typical weight (FL, P < .05 [odds ratio (OR)] = .83; FW, P < .05 [OR = .56]) and underweight (FL, P < .05 [OR = .76]; FW, P < .05 [OR = .41]) boys had significantly shorter and narrower feet. Overweight (FL, P = .02 [OR = .88]; FW, P = .02 [OR = .72]), typical weight (FL, P < .05 [OR = .77]; FW, P < .05 [OR = .47]), and underweight (FL, P < .05 [OR = .70]; FW, P < .05 [OR = .33]) girls had significantly shorter and narrower feet. These findings suggest that obesity is an important determinant of pediatric foot dimensions. Given the current prevalence of obesity in children and young people, these findings may have population-wide implications for pediatric foot health.

Musculoskeletal Fitness Measures Are Not Created Equal: An Assessment of School Children in Corpus Christi, Texas.

This study investigated current obesity prevalence and associations between musculoskeletal fitness test scores and the odds of being underweight, overweight, or obese compared to having a healthy weight in elementary school children in Corpus Christi, Texas. The sample analyzed consisted of 492 public elementary school children between kindergarten and fifth grade. Their ages ranged from 5 to 11 years. Trunk lift, 90° push-up, curl-up, and back saver sit and reach tests were administered. Weight status was determined using BMI scores and the CDC growth charts. Obesity prevalence remains high among elementary school-aged children in Corpus Christi, Texas. Higher 90° push-up test scores were most consistently associated with decreased odds of being obese as compared to being overweight and having healthy weight except in kindergarten. Conversely, higher trunk lift test scores were associated with increased odds of being obese in second and fourth grades. When children achieved the minimum score to be classified in the Healthy Fitness Zone, those with healthy weight had similarly low musculoskeletal fitness (i.e., abdominal strength and endurance, hamstring flexibility, and trunk extensor strength and flexibility) as peers with overweight and obesity, especially in the lower grades. It was concluded that increased obesity prevalence in higher grades may be precipitated (at least in part) by low musculoskeletal fitness in the lower grades, especially kindergarten. Given previous associations in the literature, low musculoskeletal fitness may be symptomatic of poor motor skill competence in the current sample. These findings suggest a need for early and focused school-based interventions that leverage both known and novel strategies to combat pediatric obesity in Corpus Christi.

Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis.

This review examined evidence of the association between maternal pre-pregnancy overweight/obesity status and child neurodevelopmental outcomes. PubMed and PsycINFO databases were systematically searched for empirical studies published before April 2017 using keywords related to prenatal obesity and children's neurodevelopment. Of 1483 identified papers, 41 were included in the systematic review, and 32 articles representing 36 cohorts were included in the meta-analysis. Findings indicated that compared with children of normal weight mothers, children whose mothers were overweight or obese prior to pregnancy were at increased risk for compromised neurodevelopmental outcomes (overweight: OR=1.17, 95% CI [1.11, 1.24], I2 =65.51; obese: OR=1.51; 95% CI [1.35, 1.69], I2 =79.63). Pre-pregnancy obesity increased the risk of attention deficit-hyperactivity disorder (OR=1.62; 95% CI [1.23, 2.14], I2 =70.15), autism spectrum disorder (OR=1.36; 95% CI [1.08, 1.70], I2 =60.52), developmental delay (OR=1.58; 95% CI [1.39, 1.79], I2 =75.77) and emotional/behavioural problems (OR=1.42; 95% CI [1.26, 1.59], I2 =87.74). Given the current obesity prevalence among young adults and women of childbearing age, this association between maternal obesity during pregnancy and atypical child neurodevelopment represents a potentially high public health burden.

Prevalence of overweight and obesity in United Arab Emirates Expatriates: the UAE National Diabetes and Lifestyle Study

ObjectiveTo describe current prevalence of obesity and related non-communicable diseases (NCDs) in expatriates living in the United Arab Emirates (UAE).MethodsWe used data from the cross-sectional UAE National Diabetes and Lifestyle Study (UAEDIAB), which surveyed adult expatriates living in the UAE for at least 4 years. We report crude prevalence of overweight and obesity, indicated by gender and ethnicity-specific body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) cut-offs, by lifestyle and biomedical characteristics, as well as age and sex-adjusted odds ratios.ResultsOut of a total of 3064 recruited expatriates (response rate 68%), 2724 had completed all stages of the UAEDIAB study. Expatriates were; 81% men, mean age 38 years (range 18–80), 71% South East Asians, and 36% university graduates. In this sample, the prevalence of overweight and obesity, by BMI, were 43.0 and 32.3%, respectively. 52.4 and 56.5% of participants were at a substantially increased risk according to WC and WHR, respectively. The prevalence of diabetes, hypertension and hypercholesterolemia were 15.5, 31.8, and 51.7%, respectively, with the prevalence of each being higher in those with obesity.ConclusionPrevalence of obesity and associated NCDs are extremely high in UAE expatriates. Without comprehensive prevention and management, levels of disease will continue to increase and productivity will fall.

Prevalence and Trends in Lifetime Obesity in the U.S., 1988–2014

Estimates of obesity prevalence based on current BMI are an important but incomplete indicator of the total effects of obesity on a population. In this study, data on current BMI and maximum BMI were used to estimate prevalence and trends in lifetime obesity status, defined using the categories never (maximum BMI ≤30 kg/m2), former (maximum BMI ≥30 kg/m2 and current BMI ≤30 kg/m2), and current obesity (current BMI ≥30 kg/m2). Prevalence was estimated for the period 2013-2014 and trends for the period 1988-2014 using data from the National Health and Nutrition Examination Survey. Predictors of lifetime weight status and the association between lifetime weight categories and prevalent disease status were also investigated using multivariable regression. A total of 50.8% of American males and 51.6% of American females were ever obese in 2013-2014. The prevalence of lifetime obesity exceeded the prevalence of current obesity by amounts that were greater for males and for older persons. The gap between the two prevalence values has risen over time. By 2013-2014, a total of 22.0% of individuals who were not currently obese had formerly been obese. For each of eight diseases considered, prevalence was higher among the formerly obese than among the never obese. A larger fraction of the population is affected by obesity and its health consequences than is suggested in prior studies based on current BMI alone. Weight history should be incorporated into routine health surveillance of the obesity epidemic for a full accounting of the effects of obesity on the U.S.

Health-related behaviour in Europe - A comparison of selected indicators for Germany and the European Union.

Demographic change, new health threats, but also inequalities in health and health care provision in and between European Union (EU) member states pose major albeit similar challenges to European health systems. Regular information on health and health-related behaviour is essential if member states' health systems are to respond and develop appropriately to these challenges. The 'European Health Interview Survey' (EHIS) is a vital source of data for indicators of health status and health-related behaviour in the EU. This article presents a comparative review of health-related behaviour at the European level. Health-related behaviour is of particular relevance because an unhealthy diet, physical inactivity, obesity, smoking, and harmful use of alcohol are among the most important determinants associated with non-communicable chronic diseases. Eurostat has used data from EHIS Wave 2 to publish details about the current prevalence of obesity, daily fruit and vegetable intake, health-enhancing aerobic physical activity, smoking and heavy episodic drinking for the EU's member states. In the following, the figures for Germany are compared to the European average. A wide range of prevalences exists between the various EU member states, in some cases stretching to more than 50 percentage points. In Germany, the prevalence of obesity and smoking remains relatively close to the EU average. Moreover, the results on physical activity are especially welcome. In particular, the proportion of women and men who undertake adequate levels of physical activity decreases more slowly with increasing age compared to the EU average. Nevertheless, the low fruit and vegetable intake, especially among younger generations, and the high proportion of women and men who drink six or more alcoholic beverages on one occasion (heavy episodic drinking) at least once a month pose problems for Germany. In summary, the results provided by EHIS offer a basis for sharing experiences between EU member states regarding effective measures in health promotion and disease prevention.

Improve Adult Health Life in Western Sydeny Through Health Promotion Models

This report will focus on a new health development initiative for the Western Sydney Adolescents and their health needs in terms of promoting physical activity and exercise because it helps them live longer and better lives and become more energetic. The target group are fairly sedentary individuals and consume copious amounts of energy dense foods, which are contributing to the burgeoning obesity risk factors in the community. A sedentary lifestyle contributes towards a range of cardiovascular diseases and health problems including heart disease, obesity, high blood pressure, high cholesterol and many types of cancers (Meyer, 2007). Successfully tackling obesity in a health promotion context, is a long-term, large-scale commitment that will require both individual responsibility and action together with a population-based approach, driven by partnerships between governments, businesses, and communities. The current prevalence of obesity in the population has been at least 30 years in the making, and will take considerable time to reverse the trends and its impacts and determinants on health (Roth, 2011). This article will outline the costing requirements and the evaluation methods that will be used in our adolescent obesity health promotion and prevention management strategy. This will be achieved by using a combination of educational and awareness campaigns, public advertising, healthy urban planning, imposing a ban on canteen junk food and establishing a health and wellbeing telephone hotline and social networking group. This will be evaluated for feasibility using cost-benefit analysis to determine whether each strategy or approach is to be implemented or not.

Shape change and obesity prevalence among male UK offshore workers after 30 years: New insight from a 3D scanning study.

In 1984, male UK offshore workers had greater overweight and obesity prevalence and fat content than the general population. Since then, body weight has increased by 19%, but, without accompanying anthropometric measures, their size increase, current obesity, and fatness prevalence remain unknown. This study therefore aimed to acquire contemporary anthropometric data, profile changes since the original survey, and assess current obesity prevalence in the male offshore workforce. A total of 588 men, recruited via quota sampling to match the workforce weight profile, underwent stature, weight, and 3D photonic scanning measurements from which anatomical girths were extracted, enabling computation of body mass index (BMI), total fat, and visceral adipose tissue (VAT). On average, UK male offshore workers are now 8.1 y older, 3.1 cm taller, 13.9 kg heavier, and have greater girths than in 1984, which are >97% attributable to increased weight, and <3% to age difference. Mean BMI increased significantly from 24.9 to 28.1 kg/m2 and of the contemporary sample, 18% have healthy weight, 52% are overweight, and 30% obese, representing an increase in overweight and obesity prevalence by 6% and 24%, respectively. Waist cutoffs identify 39% of the contemporary sample as healthy, 27% at increased health risk, and 34% at high risk. UK offshore workers today have higher BMI than Scottish men, although some muscular individuals may be misclassified by BMI. Girth data, particularly at the waist, where dimensional increase was greatest, together with predictions of total and visceral fatness, suggest less favorable health status in others.

Prevalence and Secular Trends in Obesity Among Chinese Adults, 1991-2011.

The prevalence of obesity in Chinese adults increased from 1991 to 2000; however, recent changes in this trend are unclear. This study aims to estimate the current prevalence of obesity and to assess trends in obesity and BMI distribution in Chinese adults from 1991 through 2011. Height and weight measurements of 12,249 Chinese adults from the 2011 China Health and Nutrition Survey were analyzed (in 2013) together with China Health and Nutrition Survey data for 1991-2009. Obesity was defined as BMI≥28.0 kg/m(2) based on the Working Group on Obesity in China criteria. In the 2011 survey, the age-adjusted mean BMI was 23.8 (95% CI=23.7, 23.9) for men and 23.4 (95% CI=23.2, 23.5) for women. The age-adjusted prevalence of obesity was 11.3% (95% CI=10.8%, 11.9%) overall, 11.8% (95% CI=10.8%, 12.6%) among men, and 11.0% (95% CI=10.3%, 11.8%) among women. Estimates of age-adjusted obesity prevalence among the Chinese population were significantly lower than those of the U.S. population (all p<0.05). Over the 20-year period, the prevalence of obesity increased from 2.88% to 11.8% among men (age-adjusted annual change in OR=1.08, 95% CI=1.07, 1.09, p<0.001) and from 4.55% to 11.0% among women (OR=1.05, 95% CI=1.05, 1.06, p<0.001). Similar significant findings were observed for both men and women based on WHO recommendations. The prevalence of obesity among both Chinese men and women increased significantly from 1991 through 2011, particularly among men.

PP.33.09

Objective: The study estimates current prevalence of obesity in regions of Russian Federation (RF) with different climatic, socioeconomic and demographic characteristics. Design and method: A novel epidemiology survey of cardiovascular risk in regions of RF with different climatic, geographic, economic and demographic characteristics (ESSE-RF) was performed in a multi-step stratified random sample of approximately 1600 participants in 12 selected regions. At the moment 8 regions have already recruited 13722 participants (8833 females (64%) and 4889 males (36%) aged 25–65 years. All subjects signed informed consent and filled out validated questionnaires regarding lifestyle risk factors, concomitant disease and medication. Anthropometry (height, weight with body mass index (BMI) calculation, and waist circumference (WC)) was performed. Office BP was registered by OMRON (Japan). Results: The prevalence of obesity, according to different criteria is presented in the table. They are age-adjusted according euro-standard. Both BMI and waist significantly correlated with SBP and DBP (r = 0,27, p < 0,001).Females had higher prevalence of obesity than males using any criteria (25,6% vs 29,7% and 26,4% vs 40,1% and 47,3 vs 58,1%, respectively, p < 0,01). Conclusions: The overall prevalence of obesity in Russia appears to be detected in every second subject using the WC criteria, predominantly in females. Significant discrepancies between regions exist.

Cafeteria diet impairs expression of sensory-specific satiety and stimulus-outcome learning.

A range of animal and human data demonstrates that excessive consumption of palatable food leads to neuroadaptive responses in brain circuits underlying reward. Unrestrained consumption of palatable food has been shown to increase the reinforcing value of food and weaken inhibitory control; however, whether it impacts upon the sensory representations of palatable solutions has not been formally tested. These experiments sought to determine whether exposure to a cafeteria diet consisting of palatable high fat foods impacts upon the ability of rats to learn about food-associated cues and the sensory properties of ingested foods. We found that rats fed a cafeteria diet for 2 weeks were impaired in the control of Pavlovian responding in accordance to the incentive value of palatable outcomes associated with auditory cues following devaluation by sensory-specific satiety. Sensory-specific satiety is one mechanism by which a diet containing different foods increases ingestion relative to one lacking variety. Hence, choosing to consume greater quantities of a range of foods may contribute to the current prevalence of obesity. We observed that rats fed a cafeteria diet for 2 weeks showed impaired sensory-specific satiety following consumption of a high calorie solution. The deficit in expression of sensory-specific satiety was also present 1 week following the withdrawal of cafeteria foods. Thus, exposure to obesogenic diets may impact upon neurocircuitry involved in motivated control of behavior.

Dietary energy density is associated with obesity and other biomarkers of chronic disease in US adults

Given the current prevalence of obesity, it is important to identify dietary factors that may aid in disease prevention. The objective of the present study was to evaluate the association between consumption of an energy-dense diet and established markers factors for chronic disease, including body weight and measures of body fatness. Data from a nationally representative sample of 9,551 adults ≥18 years who participated in the 2005-2008 National Health and Nutrition Examination Survey were analyzed. The association between dietary energy density (ED, energy per weight of food, kcal/g) and markers for obesity [including body mass index (BMI) and waist circumference (WC)], insulin insensitivity [including fasting glucose, insulin and homeostasis assessment model for insulin resistance (HOMA-IR)], and markers for inflammation was examined. Dietary ED was positively associated with obesity in both men and women in multivariate models. Overall, obese adults had a significantly higher dietary ED than lean adults (p < 0.0001). Current smokers had significantly higher ED than non-smokers (2.00 vs. 1.75, p < 0.01), and it was determined that smoking status modified the relationship between ED and weight status in women (p interaction 0.03). In both sexes, there was a positive linear relationship between BMI and ED (p trend 0.01 and 0.0002, respectively); a linear trend between WC and ED was also observed in women (p trend <0.001) after adjusting for relevant cofactors. In women, ED was positively associated with HOMA-IR and fasting insulin; though, this relationship was not observed in men. No significant associations between ED and C-reactive protein were observed in either sex. These findings support recent obesity and disease prevention recommendations to consume a diet low in ED.

Workplace Health: Engaging Business Leaders to Combat Obesity

This article explores how employers can be part of the solution to obesity by offering workplace wellness programs and facilitating opportunities for physical activity, access to healthier foods and beverages, and incentives for disease management and prevention to help prevent weight gain among their employees.